Currently in development, Hemanext™, is a novel, proprietary anaerobic storage system that minimizes oxidative damage to red blood cells (RBC) in storage and so delivers to patients a more physiologic, more therapeutic and potentially “fresher” red blood cell than conventional storage systems. How Hemanext keeps blood fresh »

Hemanext

Current RBC collection process and storage conditions allow RBC to exhibit cellular functional changes known as “the RBC storage lesion”. Stored RBCs, even if transfused within the current 6-week storage limit, deteriorate in a variety of significant ways, including but not limited to:

  • Hemolysis (red cell destruction)
  • Low survival rate of transfused red cells in recipients
  • Reduced deformability (inability to reach capillary beds)
  • Inability to release oxygen at tissue
  • Inability to dilate arterioles to increase tissue perfusion

A significant contributor to the storage lesion is oxidative stress resulting from exposure of the RBCs to the oxygen present throughout the collection and storage period. The resulting aerobic storage environment allows the formation of reactive oxygen species that can cause harm to RBC proteins and membrane lipids. Hemanext aims to reduce oxidative stress to the RBC during storage and in doing so to improve the benefits to patients of RBC transfusion therapy.

redefining fresh

Transfusing freshly donated blood, i.e. blood that has been stored for fewer days, has well documented patient-health advantages. The key to preserving the characteristics of RBC that make “freshness” beneficial is to inhibit the factors influencing the aging process that occurs over the permitted 42 day storage cycle. The Hemanext RBC storage system intends to reduce the oxidative stress on RBC to keep blood “fresher” longer.  Learn how.

What defines “freshness” and how fresh is blood available to patients today? Current clinical research, literature and medical practice enable us to better understand the levels of RBC “freshness” best suited to improved transfusion medicine.

fresher blood, improved transfusion therapy

At New Health Sciences, we believe that expanding access to red blood cells with “fresher” qualities may improve the safety and efficacy of routine RBC transfusion therapy.

What fresh is today

On average, current research studies define RBC aged as 9-14 days or less as “fresh” and those older than 21 days as  “old”. This suggests that in excess of 85% of RBC are not defined as “fresh” and over 30% are defined as “old”.

Fresh is put into practice by the Canadian Pediatric Society who recommends neonatal RBC transfusion be less than 5-days-old for large volume transfusions.

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Red blood cell storage lesion

storage lesion

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