Current RBC collection process and storage conditions allow RBC to exhibit cellular functional changes known as “the RBC storage lesion”. Stored RBCs, even if transfused within the current 6-week storage limit, deteriorate in a variety of significant ways, including but not limited to:
- Hemolysis (red cell destruction)
- Low survival rate of transfused red cells in recipients
- Reduced deformability (inability to reach capillary beds)
- Inability to release oxygen at tissue
- Inability to dilate arterioles to increase tissue perfusion
A significant contributor to the storage lesion is oxidative stress resulting from exposure of the RBCs to the oxygen present throughout the collection and storage period. The resulting aerobic storage environment allows the formation of reactive oxygen species that can cause harm to RBC proteins and membrane lipids. Hemanext aims to reduce oxidative stress to the RBC during storage and in doing so to improve the benefits to patients of RBC transfusion therapy.
Transfusing freshly donated blood, i.e. blood that has been stored for fewer days, has well documented patient-health advantages. The key to preserving the characteristics of RBC that make “freshness” beneficial is to inhibit the factors influencing the aging process that occurs over the permitted 42 day storage cycle. The Hemanext RBC storage system intends to reduce the oxidative stress on RBC to keep blood “fresher” longer. Learn how.
What defines “freshness” and how fresh is blood available to patients today? Current clinical research, literature and medical practice enable us to better understand the levels of RBC “freshness” best suited to improved transfusion medicine.
fresher blood, improved transfusion therapy
At New Health Sciences, we believe that expanding access to red blood cells with “fresher” qualities may improve the safety and efficacy of routine RBC transfusion therapy.
- March 22, 2013 - Jeffrey McCullough comments on the Solomon et al study about the relation between "older" blood and ...
- March 22, 2013 - Research performed by Steven B. Solomon et al show blood transfused at end of storage period incre...
- March 1, 2013 - Shareholder Meeting will take place on April 18, 2013. Details provided in March 1, 2013 Sharehold...
- March 1, 2013 - Shareholder letter added to Investor Portal...
- January 28, 2013 - Recent research by Ryan Nofziger, MD, of Nationwide Children's Hospital in Columbus, Ohio, has show...