Currently in development, Hemanext™, is a novel, proprietary anaerobic storage system that minimizes oxidative damage to red blood cells (RBC) in storage and potentially improves RBC quality across the storage cycle.

Hemanext

Current RBC collection process and storage conditions allow RBC to exhibit cellular functional changes known as “the RBC storage lesion”. Stored RBCs, even if transfused within the current 6-week storage limit, deteriorate in a variety of significant ways, including but not limited to:

  • Hemolysis (red cell destruction)
  • Low survival rate of transfused red cells in recipients
  • Reduced deformability (inability to reach capillary beds)
  • Inability to release oxygen at tissue
  • Inability to dilate arterioles to increase tissue perfusion

A significant contributor to the storage lesion is oxidative stress resulting from exposure of the RBCs to the oxygen present throughout the collection and storage period. The resulting aerobic storage environment allows the formation of reactive oxygen species that can cause harm to RBC proteins and membrane lipids.

Removing oxidative stress, improving transfusion therapy

At New Health Sciences, we believe that expanding access to red blood cells with “fresher” qualities by reducing oxidative stress during storage, may improve the benefits to patients of routine RBC transfusion therapy.

What fresh is today

On average, current research studies define RBC aged as 9-14 days or less as “fresh” and those older than 21 days as  “old”. This suggests that in excess of 85% of RBC are not defined as “fresh” and over 30% are defined as “old”.

Fresh is put into practice by the Canadian Pediatric Society who recommends neonatal RBC transfusion be less than 5-days-old for large volume transfusions.

chart

Red blood cell storage lesion

storage lesion

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